A hazmat fee may apply, depending on the amount ordered.
DMSO: 175mg/mL; H2O: <1mg/mL; EtOH: 28mg/mL
Antiparasitic Agent; Insecticide
REVIEW Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Ivermectin may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms.
Pampiglione S, Majori G, Petrangeli G, Romi R (1985). Avermectins, MK-933 and MK-936, for mosquito control. Trans R Soc Trop Med Hyg 79 (6): 797-9. doi:10.1016/0035-9203(85)90121-X. PMID 3832491.
Victoria J, Trujillo R (2001). Topical ivermectin: a new successful treatment for scabies. Pediatr Dermatol 18 (1): 63-5. doi:10.1046/j.1525-1470.2001.018001063.x. PMID 11207977.
Dourmishev AL, Dourmishev LA, Schwartz RA (December 2005). Ivermectin: pharmacology and application in dermatology. International Journal of Dermatology 44 (12): 981-8. doi:10.1111/j.1365-4632.2004.02253.x. PMID 16409259.
Strycharz JP, Yoon KS, Clark JM (January 2008). A new ivermectin formulation topically kills permethrin-resistant human head lice (Anoplura: Pediculidae). Journal of Medical Entomology 45 (1): 75-81. doi:10.1603/0022-2585(2008)45[75:ANIFTK]2.0.CO;2. ISSN 0022-2585. PMID 18283945.
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