52-49-3, 58947-95-8 DL-Trihexyphenidyl hydrochloride AKSci J10177
 
 
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  J10177    AKSci Reference Standard
DL-Trihexyphenidyl hydrochloride
, >98% (HPLC), powder
 
Benzhexol hydrochloride




IDENTITY
CAS Number:52-49-3, 58947-95-8
MDL Number:MFCD00058212
MF:C20H32ClNO
MW:337.93
EINECS:2933.39.9100
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:114-115°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O: soluble

REVIEW

 Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.

REFERENCES
[1]Giachetti, A.; Giraldo, E.; Ladinsky, H.; Montagna, E. (1986). Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine. British Journal of Pharmacology 89 (1): 83-90. PMC 1917044. PMID 2432979.
[2] Berke, J. D.; Hyman, S. E. (2000). Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25 (3): 515-532. doi:10.1016/S0896-6273(00)81056-9. PMID 10774721.
[3] Sanger, T. D.; Bastian, A.; Brunstrom, J.; Damiano, D.; Delgado, M.; Dure, L.; Gaebler-Spira, D.; Hoon, A. et al. (2007). Prospective Open-Label Clinical Trial of Trihexyphenidyl in Children with Secondary Dystonia due to Cerebral Palsy. Journal of Child Neurology 22 (5): 530-537. doi:10.1177/0883073807302601. PMID 17690057.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of October 2, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > AChR Agonists


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