18559-94-9 Salbutamol AKSci J10176
 
 
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  J10176    
Salbutamol
, 99% (HPLC)
 
alpha-[(t-Butylamino)methyl]-4-hydroxy-m-xylene-alpha,alpha'-diol
Albuterol




IDENTITY
CAS Number:18559-94-9
MDL Number:MFCD00148978
MF:C13H21NO3
MW:239.31
EINECS:242-424-0
BRN:6405698
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:157-166°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in most organic solvents
Application(s):Short-acting beta-2-adrenergic receptor agonist

REVIEW

 Salbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increases cAMP production by activating adenylate cyclase, and the actions of salbutamol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentration leads to a smooth muscle relaxation and bronchodilation. In addition to bronchodilation, salbutamol inhibits the release of bronchoconstricting agents from mast cells, inhibits microvascular leakage, and enhances mucociliary clearance.

REFERENCES
[1]Van Meerbeke, J. P.; Sumner, C. J. (2011). Progress and promise: The current status of spinal muscular atrophy therapeutics. Discovery medicine 12 (65): 291-305. PMID 22031667.
[2] Carter WJ, Lynch ME (September 1994). Comparison of the effects of salbutamol and clenbuterol on skeletal muscle mass and carcass composition in senescent rats. Metab. Clin. Exp. 43 (9): 1119-25. doi:10.1016/0026-0495(94)90054-X. PMID 7916118.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of May 21, 2024


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CATEGORIES

 APIs and Bioactives > Adrenergic Agonists


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