88495-63-0 Artesunate AKSci J10169
 
 
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  J10169    AKSci Reference Standard
Artesunate, >98% (HPLC)
 



IDENTITY
CAS Number:88495-63-0
MDL Number:MFCD00866204
MF:C19H28O8
MW:384.42
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:136-140°C
Optical Rotation:+4.5 to +6.5° (c=1, CH2Cl2)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml)
Application(s):Artemisinin group of agents

REVIEW
 Artesunate is part of the artemisinin group of drugs that treat malaria, which is a semi-synthetic derivative of artemisinin that is water-soluble. It has also been shown to effective against other parasites such as liver flukes. Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types.

REFERENCES
[1]Boulangier D, Dieng Y, Cisse B, et al. (2007). Antischistosomal efficacy of artesunate combination therapies administered as curative treatments for malaria attacks. Trans R Soc Trop Med Hyg 101 (2): 113-16. PMID 16765398.
[2] Efferth, T., et. al. Molecular modes of action of artesunate in tumor cell lines. Mol. Pharmacol. 64, 382-394, (2003) .
[3] Keiser, J., et. al. Antimicrob. Agents Chemother. 57, 1139-1145, (2006).

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P312; P322; P330; P363; P501

Current as of October 16, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antimalarials


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