57-83-0 Progesterone AKSci J10165
 
 
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  J10165    
Progesterone
, >99% (HPLC)
 
4-Pregnene-3,20-dione
Prometrium
Agolutin
more..




IDENTITY
CAS Number:57-83-0
MDL Number:MFCD00003658
MF:C21H30O2
MW:314.46
EINECS:200-350-6
SPECIFICATIONS & PROPERTIES
Purity:>99% (HPLC)
Spectra:NMR, FT-IR, LCMS, HPLC, Polarimetry
Physical Form:White powder
Melting Point:126-134°C
Optical Rotation:+179° - +185° (c=2, Dioxane)
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: 22mg/mL; H2O: <1mg/mL; EtOH: 63mg/mL
Application(s):Progesterone receptor; Mineralocorticoid receptor antagonist
Form:Free Base

REVIEW

 Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity.

REFERENCES
[1]Allen WM: THE ISOLATION OF CRYSTALLINE PROGESTIN. Science. 1935 Aug 2;82(2118):89-93.
[2] Allen WM: Progesterone: how did the name originate? South Med J. 1970 Oct;63(10):1151-5.
[3] Schumacher M, Guennoun R, Robert F, Carelli C, Gago N, Ghoumari A, Gonzalez Deniselle MC, Gonzalez SL, Ibanez C, Labombarda F, Coirini H, Baulieu EE, De Nicola AF: Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination. Growth Horm IGF Res. 2004 Jun;14 Suppl A:S18-33.
[4] Hould FS, Fried GM, Fazekas AG, Tremblay S, Mersereau WA: Progesterone receptors regulate gallbladder motility. J Surg Res. 1988 Dec;45(6):505-12.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H351; H361

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501


Current as of December 14, 2018


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CATEGORIES

 APIs and Bioactives > Steroid Hormones


PubChem