Soluble in DMSO (>20 mg/ml), methanol (10 mg/ml), DMF (~30 mg/ml), ethanol (~50 mg/ml), and 1:1 ethanol:PBS(pH 7.2) (~0.15 mg/ml). Insoluble in water
REVIEW Pterostilbene, is a compound originally derived from Pterocarpus marsupium. It has been shown to be a free radical scavenger as well as a moderate inhibitor of Cox-1 (IC50 = 19.8 µM) and Cox-2 (IC50 = 83.9 µM). Pterostilbene has also been reported to induce PPARalpha (peroxisome proliferator-activated receptor alpha), which causes a decrease in lipid and glucose concentration. Additional experiments have shown that Pterostilbene also suppresses Azoxymethane induced formation of aberrant crypt foci in male rats. IC50 data: COX-1: IC50 = 19.8 µM; COX-2: IC50 = 83.9 µM; apoptosis: IC50 = 70 µM (HL60 cells); synthesis of prostaglandin E2: IC50 = 1.0 µM (lipopolysaccharide-stimulated human peripheral blood mononuclear cells); cell proliferation: IC50 = ~60 µM. Ki data: Ki= 0.57 µM (cytochrome P450 1A1).
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