537-42-8 Pterostilbene AKSci J10149
 
 
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  J10149    AKSci Reference Standard
Pterostilbene, 99% (HPLC)
 
trans-1-(3,5-Dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene, 4'-Hydroxy-3,5-dimethoxy-trans-stilbene
IDENTITY
CAS Number:537-42-8
MDL Number:MFCD00238710
MF:C16H16O3
MW:256.3
BRN:6(4)7592
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:95-98°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in DMSO (>20 mg/ml), methanol (10 mg/ml), DMF (~30 mg/ml), ethanol (~50 mg/ml), and 1:1 ethanol:PBS(pH 7.2) (~0.15 mg/ml). Insoluble in water

REVIEW
 Pterostilbene, is a compound originally derived from Pterocarpus marsupium. It has been shown to be a free radical scavenger as well as a moderate inhibitor of Cox-1 (IC50 = 19.8 µM) and Cox-2 (IC50 = 83.9 µM). Pterostilbene has also been reported to induce PPARalpha (peroxisome proliferator-activated receptor alpha), which causes a decrease in lipid and glucose concentration. Additional experiments have shown that Pterostilbene also suppresses Azoxymethane induced formation of aberrant crypt foci in male rats. IC50 data: COX-1: IC50 = 19.8 µM; COX-2: IC50 = 83.9 µM; apoptosis: IC50 = 70 µM (HL60 cells); synthesis of prostaglandin E2: IC50 = 1.0 µM (lipopolysaccharide-stimulated human peripheral blood mononuclear cells); cell proliferation: IC50 = ~60 µM. Ki data: Ki= 0.57 µM (cytochrome P450 1A1).

REFERENCES
[1]Manickam, M., et al. 1997. J. Nat. Prod. 60: 609-610. PMID: 9214733.
[2] Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50: 3453-3457. PMID: 12033810.
[3] Rimando, A.M., et al. 2005. J. Agric. Food Chem. 53: 3403-3407. PMID: 15853379.
[4] Suh, N., et al. 2007. Clin. Cancer Res. 13: 350-355. PMID: 17200374.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H318; H411

Precautionary Statements
P273; P280; P305+P351+P338; P310; P391; P501

Current as of September 15, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Natural Products, Stilbenoids


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