[305-01-1] Esculetin AKSci J10146
 
 
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  J10146    
Esculetin
, 99% (HPLC)
 
6,7-Dihydroxycoumarin




IDENTITY
CAS Number:[305-01-1]
MDL Number:MFCD00006874
MF:C9H6O4
MW:178.14
EINECS:206-161-5
BRN:152788
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Available Spectra:NMR, LCMS, HPLC
Physical Form:Light yellow to yellow to green-yellow to brown crystals or powder
Melting Point:254-273°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Application(s):A phenolic compound that acts as a 5-LO and 12-LO inhibitor

REVIEW

 Esculetin, a phenolic compound, acts as a 5-LO (5-lipoxygenase; 5-LOX) inhibitor. Esculetin is reported to display anti-inflammatory and antioxidant properties, as well as induce cell cycle arrest and apoptosis. In the presence of Esculetin and HA14-1 expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that Esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. Additionally, reports demonstrate that Esculetin also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition. IC50 data: ATPase: IC50 = 11.33 µM; A23187-induced LTC4 release: IC50 = 18 µM (mouse macrophage); A23187-induced PGE2 release: IC50 = 11 µM (mouse macrophage); Xanthine Oxidase: IC50 = 8.2 µM (human).

REFERENCES
[1]Neichi, T., et al. 1983. Biochim. Biophys. Acta. 753: 130-132. PMID: 6411127.
[2] Du, L., et al. 2006. J. Biochem. 139: 715-723. PMID: 16672272.
[3] Kok, S.H., et al. 2009. Oral Oncol. 45: 1067-1072. PMID: 19720557.
[4] Witaicenis, A., et al. 2010. Chem. Biol. Interact. 186: 211-218. PMID: 20380826.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 22, 2017


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CATEGORIES

 APIs and Bioactives > Natural Products


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