REVIEW One of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery.
REFERENCES
[1]
Chappell LC, Gurung V, Seed PT, Chambers J, Williamson C, Thornton JG; PITCH Study Consortium (2012). Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. BMJ. 344:e3799. PMID 22695903.
[2]
Peir?-Jord?n R, Krishna-Subramanian S, Hanski ML, L?scher-Firzlaff J, Zeitz M, Hanski C (2012). The chemopreventive agent ursodeoxycholic acid inhibits proliferation of colon carcinoma cells by suppressing c-Myc expression. Eur J Cancer Prev. 21(5):413-22. PMID 22395148.
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