128-13-2 Ursodeoxycholic acid AKSci J10139
 
 
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  J10139    AKSci Reference Standard
Ursodeoxycholic acid, 99%, powder
 
Ursodiol
UDCA
Ursosan
more..
IDENTITY
CAS Number:128-13-2
MDL Number:MFCD00003680
MF:C24H40O4
MW:392.57
EINECS:204-879-3
BRN:3219888
SPECIFICATIONS & PROPERTIES
Purity:99%, powder
Spectra:LCMS, FT-IR, HPLC, Polarimetry
Physical Form:White to off-white powder
Melting Point:203-206°C
Optical Rotation:+57-+62° (c=2,EtOH)
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: 79mg/mL; H2O: <1mg/mL; EtOH: 79mg/mL
Application(s):Apoptosis inhibitor
Form:Free Base

REVIEW
 One of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery.

REFERENCES
[1]Chappell LC, Gurung V, Seed PT, Chambers J, Williamson C, Thornton JG; PITCH Study Consortium (2012). Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. BMJ. 344:e3799. PMID 22695903.
[2] Peir?-Jord?n R, Krishna-Subramanian S, Hanski ML, L?scher-Firzlaff J, Zeitz M, Hanski C (2012). The chemopreventive agent ursodeoxycholic acid inhibits proliferation of colon carcinoma cells by suppressing c-Myc expression. Eur J Cancer Prev. 21(5):413-22. PMID 22395148.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of July 9, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Bile Acids


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