33286-22-5 Diltiazem HCl AKSci J10138
 
 
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  J10138    AKSci Reference Standard
Diltiazem HCl
, >99% (HPLC)
 
(+)-cis-Diltiazem hydrochloride
(2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401




IDENTITY
CAS Number:33286-22-5
MDL Number:MFCD00069252
MF:C22H26N2O4S.HCl
MW:450.98
EINECS:251-443-3
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:210-216°C
Optical Rotation:+114.0° - +122.0° (c=1, H2O)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Benzothiazepine derivative
Form:HCl salt

REVIEW

 Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of October 2, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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⚠️
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New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Diltiazem HCl, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.



CATEGORIES

 APIs and Bioactives > Arrhythmia, Calcium Channel Blockers


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