33286-22-5 Diltiazem HCl AKSci J10138
 
 
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  J10138    AKSci Reference Standard
Diltiazem HCl
, >99% (HPLC)
 
(+)-cis-Diltiazem hydrochloride
(2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401




IDENTITY
CAS Number:33286-22-5
MDL Number:MFCD00069252
MF:C22H26N2O4S.HCl
MW:450.98
EINECS:251-443-3
SPECIFICATIONS & PROPERTIES
Purity:>99% (HPLC)
Spectra:NMR, HPLC, LCMS, Polarimetry
Physical Form:White to off-white powder
Melting Point:210-216°C
Optical Rotation:+114.0° - +122.0° (c=1, H2O)
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Application(s):Benzothiazepine derivative
Form:HCl salt

REVIEW

 Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of March 25, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Arrhythmia, Calcium Channel Blockers


PubChem