82410-32-0 Ganciclovir AKSci J10127
 
 
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  J10127    
Ganciclovir
, >98% (HPLC)
 
9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine
2-Amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-1H-purin-6(9H)-one




IDENTITY
CAS Number:82410-32-0
MDL Number:MFCD00870588
MF:C9H13N5O4
MW:255.23
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:251-256°C
Long-Term Storage:Store long-term at 2-8°C
Note:Loss on drying max 6.0%
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:0.1M HCl: 10mg/mL; DMSO: 50mg/mL; H2O: insoluble

REVIEW

 Ganciclovir''s antiviral activity inhibits virus replication. This inhibitory action is highly selective as the drug must be converted to the active form by a virus-encoded cellular enzyme, thymidine kinase (TK). TK catalyzes phosphorylation of ganciclovir to the monophosphate, which is then subsequently converted into the diphosphate by cellular guanylate kinase and into the triphosphate by a number of cellular enzymes. In vitro, ganciclovir triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, ganciclovir triphosphate competitively inhibits dATP leading to the formation of ''faulty'' DNA. This is where ganciclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand. Ganciclovir inhibits viral DNA polymerases more effectively than it does cellular polymerase, and chain elongation resumes when ganciclovir is removed.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H360

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501


Current as of October 15, 2024


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CATEGORIES

 APIs and Bioactives > Antivirals


PubChem