73590-58-6 Omeprazole AKSci J10125
 
 
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  J10125    
Omeprazole, >98% (HPLC), powder
 
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
Losec
Omesec
more..
IDENTITY
CAS Number:73590-58-6
MDL Number:MFCD00083192
MF:C17H19N3O3S
MW:345.42
EINECS:200-659-6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:156-160°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 69mg/mL; H2O: <1mg/mL; EtOH: 15mg/mL
Application(s):Proton-pump inhibitor (PPI); Enzyme Inhibitor
Form:Free Base

REVIEW
 Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By acting specifically on the proton pump, omeprazole blocks the final step in acid production, thus reducing gastric acidity.

REFERENCES
[1]Yang YX, Lewis JD, Epstein S, Metz DC: Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006 Dec 27;296(24):2947-53.
[2] Kahrilas PJ, Jonsson A, Denison H, Wernersson B, Hughes N, Howden CW (2012). Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 10(6):612-9. PMID 22343515.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 13, 2025


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CATEGORIES
 APIs and Bioactives > Proton Pump Inhibitors


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