[64-86-8] Colchicine AKSci J10109
 
 
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  J10109    
Colchicine
, 98% (HPLC)
 
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide




IDENTITY
CAS Number:[64-86-8]
MDL Number:MFCD00078484
MF:C22H25NO6
MW:399.44
EINECS:200-598-5
BRN:2228813
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:NMR, FT-IR, LCMS, HPLC, Polarimetry
Physical Form:White to light yellow scales or powder
Melting Point:154-161°C (dec)
Optical Rotation:-230° ~ -245° (c=1, Ethanol)
Long-Term Storage:Store at room temperature
UN #:UN1544
Hazard Class:6.1
Packing Group:I

REVIEW

 Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

REFERENCES
[1]Hwang, D.; Wang, J.; Li, W.; Miller, D. D. Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents. ACS Med. Chem. Lett. 2015, 6 (9), 993-997.
[2] Kuroiwa, K.; Ishii, H.; Matsuno, K.; Asai, A.; Suzuki, Y. Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents. ACS Med. Chem. Lett. 2015, 6 (3), 287-291.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H300+H330; H318; H340

Precautionary Statements
P201; P202; P260; P264; P270; P271; P280; P284; P301+P310; P304+P340; P305+P351+P338; P310; P320; P330; P403+P233; P405; P501


Current as of December 14, 2017


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CATEGORIES

 APIs and Bioactives > Natural Products


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