2353-33-5 Decitabine AKSci J10097
 
 
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  J10097    AKSci Reference Standard
Decitabine
, 99% (HPLC)
 
5-Aza-2'-deoxycytidine




IDENTITY
CAS Number:2353-33-5
MDL Number:MFCD00043011
MF:C8H12N4O4
MW:228.21
EINECS:219-089-4
BRN:617982
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:206-212°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO
Application(s):Inhibitor of DNA methylation
Form:Free base
Research Area:Ovarian Cancer, myelodysplastic syndromes

REVIEW

 Decitabine is a cytidine antimetabolite nucleoside analogue with potential antineoplastic activity. The incorporation of Decitabine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence. This adversely affects the way that cell regulatory proteins are able to bind to the DNA/RNA substrate. It is used for the treatment of patients with myelodysplastic syndromes (MDS).

REFERENCES
[1]Marks, Peter W. Decitabine for acute myeloid leukemia. Expert Review of Anticancer Therapy. (2012) 12(3): 299-305.
[2] Santos, Fabio P. S.; Kantarjian, Hagop; Garcia-Manero, Guillermo; Issa, Jean-Pierre; Ravandi, Farhad. Decitabine in the treatment of myelodysplastic syndromes. Expert Review of Anticancer Therapy. (2010) 10(1): 9-22.
[3] van Camp, Jennifer A. Decitabine (Dacogen): A DNA methyltransferase inhibitor for cancer Edited by Li, Jie Jack; Johnson, Douglas S. Modern Drug Synthesis (2010): 47-55.
[4] Pliml, J.; Sorm, F.Synthesis of 2-deoxy-D-ribofuranosyl-5-azacytosine Collection of Czechoslovak Chemical Communications (1964), 29, 2576-8.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H302; H315; H319; H335; H341; H360

Precautionary Statements
P201; P202; P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P308+P313; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of April 24, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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