REVIEW A loop diuretic of the sulfamyl category to treat heart failure. In the brain, bumetanide blocks the NKCC1 cation-chloride co-transporter, and thus decreases internal chloride concentration in neurons. In turn, this concentration change makes the action of GABA more hyperpolarizing, which may be useful for treatment of neonatal seizures, that quite often are not responsive to traditional GABA-targeted treatment.
REFERENCES
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Algharabil J, Kintner DB, Wang Q, Begum G, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D (2012). Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells. Cell Physiol Biochem. 30(1):33-48. PMID 22759954.
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Yang Y, Fu A, Wu X, Reagan JD (2012). GPR35 is a target of the loop diuretic drugs bumetanide and furosemide. Pharmacology. 89(1-2):13-7. PMID 22236570.
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