55mg/ml in Methanol: clear to slightly hazy colorless solution
REVIEW Hydrochlorothiazide, (also knowns as HCTZ, HCT, HZT and water pill), is a thiazide diuretic drug that acts by inhibiting the kidneys'' ability to retain or rebsorb water and electrolytes. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. Overall this reduces the volume of the blood, decreasing blood return to the heart and thus cardiac output and, by other mechanisms, is believed to lower peripheral vascular resistance. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
REFERENCES
[1]
Dvorak MM, De Joussineau C, Carter DH et al. (2007). Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by targeting a NaCl cotransporter in bone, J. Am. Soc. Nephrol. 18 (9): 2509-16.
[2]
Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010;8(6):793-802.
[3]
Freis ED. Effectiveness of drug therapy in hypertension: present status. A review. Circ Res. 1971;28(5):Suppl 2:70-5.
[4]
EARLEY LE, ORLOFF J THIAZIDE DIURETICS., Annu Rev Med. 1964;15:149-66.
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