58-93-5 Hydrochlorothiazide AKSci J10079
 
 
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  J10079    AKSci Reference Standard
Hydrochlorothiazide
, >98% (HPLC)
 
Dichlotride
Hydrosaluric
Hypothiazide
more..




IDENTITY
CAS Number:58-93-5
MDL Number:MFCD00051765
MF:C7H8ClN3O4S2
MW:297.74
EINECS:200-403-3
BRN:625101
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White to light yellow crystalline powder
Melting Point:266-276°C
Density:1.694
Refractive Index:1.632
Long-Term Storage:Store at room temperature
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:55mg/ml in Methanol: clear to slightly hazy colorless solution

REVIEW

 Hydrochlorothiazide, (also knowns as HCTZ, HCT, HZT and water pill), is a thiazide diuretic drug that acts by inhibiting the kidneys'' ability to retain or rebsorb water and electrolytes. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. Overall this reduces the volume of the blood, decreasing blood return to the heart and thus cardiac output and, by other mechanisms, is believed to lower peripheral vascular resistance. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

REFERENCES
[1]Dvorak MM, De Joussineau C, Carter DH et al. (2007). Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by targeting a NaCl cotransporter in bone, J. Am. Soc. Nephrol. 18 (9): 2509-16.
[2] Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010;8(6):793-802.
[3] Freis ED. Effectiveness of drug therapy in hypertension: present status. A review. Circ Res. 1971;28(5):Suppl 2:70-5.
[4] EARLEY LE, ORLOFF J THIAZIDE DIURETICS., Annu Rev Med. 1964;15:149-66.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 20, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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