50-24-8 Prednisolone AKSci J10078

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J10078 AKSci Reference Standard
Prednisolone, >98% (HPLC)

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11beta,17alpha,21-Trihydroxypregna-1,4-diene-3,20-dione

1-Dehydrohydrocortisone

1-Dehydrocortisol

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IDENTITY
CAS Number:	50-24-8
MDL Number:	MFCD00003649
MF:	C21H28O5
MW:	360.44
EINECS:	200-021-7

SPECIFICATIONS & PROPERTIES
Purity:	>98% (HPLC)
Spectra:	LCMS, HPLC
Physical Form:	White fluffy powder
Melting Point:	240°C (dec.)
Optical Rotation:	+97° - +103° (c=1, Dioxane)
Long-Term Storage:	Store at room temperature

BIOLOGICAL INFO
Solubility:	MeOH
Application(s):	Antineoplastic Agent; Glucocorticoid
Form:	Free Base

REVIEW
Prednisolone is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and auto-immune conditions. Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity.

REFERENCES

[1]	Klaasen R, Herenius MM, Wijbrandts CA, de Jager W, van Tuyl LH, Nurmohamed MT, Prakken BJ, Gerlag DM, Tak PP (2012). Treatment-specific changes in circulating adipocytokines: a comparison between tumour necrosis factor blockade and glucocorticoid treatment for rheumatoid arthritis. Ann Rheum Dis. 71(9):1510-6. PMID 22440821.
[2]	Ahmed HH, Morcos NY, Eskander EF, Seoudi DM, Shalby AB (2012). Potential role of leptin against glucocorticoid-induced secondary osteoporosis in adult female rats. Eur Rev Med Pharmacol Sci. 16(10):1446-52. PMID 23104664.

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