50-24-8, 52438-85-4 Prednisolone AKSci J10078
 
 
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  J10078    AKSci Reference Standard
Prednisolone, >98% (HPLC)
 
11beta,17alpha,21-Trihydroxypregna-1,4-diene-3,20-dione
1-Dehydrohydrocortisone
1-Dehydrocortisol
more..
IDENTITY
CAS Number:50-24-8, 52438-85-4
MDL Number:MFCD00003649
MF:C21H28O5
MW:360.44
EINECS:200-021-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:240°C (dec.)
Optical Rotation:+97° - +103° (c=1, Dioxane)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:MeOH
Application(s):Antineoplastic Agent; Glucocorticoid
Form:Free Base

REVIEW
 Prednisolone is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and auto-immune conditions. Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity.

REFERENCES
[1]Klaasen R, Herenius MM, Wijbrandts CA, de Jager W, van Tuyl LH, Nurmohamed MT, Prakken BJ, Gerlag DM, Tak PP (2012). Treatment-specific changes in circulating adipocytokines: a comparison between tumour necrosis factor blockade and glucocorticoid treatment for rheumatoid arthritis. Ann Rheum Dis. 71(9):1510-6. PMID 22440821.
[2] Ahmed HH, Morcos NY, Eskander EF, Seoudi DM, Shalby AB (2012). Potential role of leptin against glucocorticoid-induced secondary osteoporosis in adult female rats. Eur Rev Med Pharmacol Sci. 16(10):1446-52. PMID 23104664.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of October 6, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Immunomodulators


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