59-66-5 Acetazolamide AKSci J10059
 
 
Loading Please Wait...
  J10059    AKSci Reference Standard
Acetazolamide
, 99% (HPLC), powder
 
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
5-Acetamido-1,3,4-thiadiazole-2-sulfonamide
N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide




IDENTITY
CAS Number:59-66-5
MDL Number:MFCD00003105
MF:C4H6N4O3S2
MW:222.25
EINECS:200-440-5
BRN:212994
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC), powder
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:276-281°C
Long-Term Storage:Store at room temperature

REVIEW

 Acetazolamide is a carbonic anhydrase inhibitor used as a diuretic. It is used for the treatment of moderate to severe metabolic or respiratory alkalosis by interfering with bicarbonate reabsorption in the kidneys, thereby re-acidifying the blood and making the urine more basic.

REFERENCES
[1]Osowski, Antoni; Klecha, Urszula; Dereszynski, Henryk; Adamiak, Kazimierz Method for manufacturing 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide Pol. (1991), PL 152632 B1 19910131.
[2] Leaf DE, Goldfarb DS Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness.J Appl Physiol (1985). 2007 Apr;102(4):1313-22.
[3] Dickinson JG. Acetazolamide in acute mountain sickness. Br Med J (Clin Res Ed). 1987 Nov 7;295(6607):1161-2.
[4] Reiss WG, Oles KS. Acetazolamide in the treatment of seizures. Ann Pharmacother. 1996 May;30(5):514-9.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319

Precautionary Statements
P264; P280; P302+P352; P305+P351+P338; P321; P332+P313; P337+P313; P362


Current as of October 16, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use.
Not for human use.

WARNING: Attention California residents: This product can expose you to chemicals including Acetazolamide, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES

 APIs and Bioactives > Carbonic Anhydrase Inhibitors


PubChem
  @PubMed