59-66-5 Acetazolamide AKSci J10059
 
 
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  J10059    AKSci Reference Standard
Acetazolamide
, 99% (HPLC), powder
 
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
5-Acetamido-1,3,4-thiadiazole-2-sulfonamide
N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide




IDENTITY
CAS Number:59-66-5
MDL Number:MFCD00003105
MF:C4H6N4O3S2
MW:222.25
EINECS:200-440-5
BRN:212994
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC), powder
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:276-281°C
Long-Term Storage:Store at room temperature

REVIEW

 Acetazolamide is a carbonic anhydrase inhibitor used as a diuretic. It is used for the treatment of moderate to severe metabolic or respiratory alkalosis by interfering with bicarbonate reabsorption in the kidneys, thereby re-acidifying the blood and making the urine more basic.

REFERENCES
[1]Osowski, Antoni; Klecha, Urszula; Dereszynski, Henryk; Adamiak, Kazimierz Method for manufacturing 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide Pol. (1991), PL 152632 B1 19910131.
[2] Leaf DE, Goldfarb DS Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness.J Appl Physiol (1985). 2007 Apr;102(4):1313-22.
[3] Dickinson JG. Acetazolamide in acute mountain sickness. Br Med J (Clin Res Ed). 1987 Nov 7;295(6607):1161-2.
[4] Reiss WG, Oles KS. Acetazolamide in the treatment of seizures. Ann Pharmacother. 1996 May;30(5):514-9.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319

Precautionary Statements
P264; P280; P302+P352; P305+P351+P338; P321; P332+P313; P337+P313; P362


Current as of June 27, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Carbonic Anhydrase Inhibitors


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