59-66-5 Acetazolamide AKSci J10059
 
 
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  J10059    AKSci Reference Standard
Acetazolamide, 99% (HPLC), powder
 
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
5-Acetamido-1,3,4-thiadiazole-2-sulfonamide
N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide
IDENTITY
CAS Number:59-66-5
MDL Number:MFCD00003105
MF:C4H6N4O3S2
MW:222.25
EINECS:200-440-5
BRN:212994
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:276-281°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Acetazolamide is a carbonic anhydrase inhibitor used as a diuretic. It is used for the treatment of moderate to severe metabolic or respiratory alkalosis by interfering with bicarbonate reabsorption in the kidneys, thereby re-acidifying the blood and making the urine more basic.

REFERENCES
[1]Osowski, Antoni; Klecha, Urszula; Dereszynski, Henryk; Adamiak, Kazimierz Method for manufacturing 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide Pol. (1991), PL 152632 B1 19910131.
[2] Leaf DE, Goldfarb DS Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness.J Appl Physiol (1985). 2007 Apr;102(4):1313-22.
[3] Dickinson JG. Acetazolamide in acute mountain sickness. Br Med J (Clin Res Ed). 1987 Nov 7;295(6607):1161-2.
[4] Reiss WG, Oles KS. Acetazolamide in the treatment of seizures. Ann Pharmacother. 1996 May;30(5):514-9.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319

Precautionary Statements
P264; P280; P302+P352; P305+P351+P338; P321; P332+P313; P337+P313; P362

Current as of March 26, 2023

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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⚠️
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Acetazolamide, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Carbonic Anhydrase Inhibitors


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