59-66-5 Acetazolamide AKSci J10059
 
 
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  J10059    AKSci Reference Standard
Acetazolamide, 99% (HPLC), powder
 
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
5-Acetamido-1,3,4-thiadiazole-2-sulfonamide
N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide
IDENTITY
CAS Number:59-66-5
MDL Number:MFCD00003105
MF:C4H6N4O3S2
MW:222.25
EINECS:200-440-5
BRN:212994
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:276-281°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Acetazolamide is a carbonic anhydrase inhibitor used as a diuretic. It is used for the treatment of moderate to severe metabolic or respiratory alkalosis by interfering with bicarbonate reabsorption in the kidneys, thereby re-acidifying the blood and making the urine more basic.

REFERENCES
[1]Osowski, Antoni; Klecha, Urszula; Dereszynski, Henryk; Adamiak, Kazimierz Method for manufacturing 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide Pol. (1991), PL 152632 B1 19910131.
[2] Leaf DE, Goldfarb DS Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness.J Appl Physiol (1985). 2007 Apr;102(4):1313-22.
[3] Dickinson JG. Acetazolamide in acute mountain sickness. Br Med J (Clin Res Ed). 1987 Nov 7;295(6607):1161-2.
[4] Reiss WG, Oles KS. Acetazolamide in the treatment of seizures. Ann Pharmacother. 1996 May;30(5):514-9.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319

Precautionary Statements
P264; P280; P302+P352; P305+P351+P338; P321; P332+P313; P337+P313; P362

Current as of September 19, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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All batches backed with full quality assurance.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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WARNING: Attention California residents: This product can expose you to chemicals including Acetazolamide, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Carbonic Anhydrase Inhibitors


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