144689-63-4 Olmesartan medoxomil AKSci J10058
 
 
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  J10058    AKSci Reference Standard
Olmesartan medoxomil, >98% (HPLC)
 
Benicar
IDENTITY
CAS Number:144689-63-4
MDL Number:MFCD00944911
MF:C29H30N6O6
MW:558.59
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Physical Form:White to off-white powder
Melting Point:180-188°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Application(s):Angiotensin II receptor antagonist

REVIEW
 Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation and renal reabsorption of sodium. Olmesartan blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle. Its action is, therefore, independent of the pathways for angiotensin II synthesis. Olmesartan has more than a 12,500-fold greater affinity for the AT1 receptor than for the AT2 receptor.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of July 13, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Angiotensin Receptor Blockers


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