100986-85-4 Levofloxacin AKSci J10056
 
 
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  J10056    AKSci Reference Standard
Levofloxacin, 99% (HPLC), powder
 



IDENTITY
CAS Number:100986-85-4
MDL Number:MFCD07772024
MF:C18H20FN3O4
MW:361.37
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:220-225°C
Optical Rotation:-92° - -106° (c=0.5, MeOH)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:CHCl3; MeOH
Application(s):Antibiotic; Anti-Infective Agent; Nucleic Acid Synthesis Inhibitor
Form:Hydrate

REVIEW
 Levofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase iv, which is an enzyme necessary to separate replicated DNA, thereby inhibiting cell division.

REFERENCES
[1]Miyake T, Ito N, Tajima K, Goto H, Furukawa T (2012). Comparison of moxifloxacin and levofloxacin in an epithelial disorder model using cultured rabbit corneal epithelial cell sheets. Graefes Arch Clin Exp Ophthalmol. 250(7):1035-41. PMID 22282216.
[2] Sun J, Song M, Feng J, Pi Y (2012). Highly efficient degradation of ofloxacin by UV/Oxone/Co2+ oxidation process. Environ Sci Pollut Res Int. 19(5):1536-43. PMID 22072118.
[3] Milder E, Vander J, Shah C, Garg S (2012). Changes in antibiotic resistance patterns of conjunctival flora due to repeated use of topical antibiotics after intravitreal injection. Ophthalmology. 119(7):1420-4. PMID 22420958.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H302; H317; H334; H361; H362

Precautionary Statements
P201; P202; P260; P263; P264; P270; P272; P280; P301+P312; P302+P352; P304+P341; P308+P313; P321; P330; P333+P313; P363; P405; P501

Current as of August 16, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antibacterials, Quinolones


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