[302-79-4] Retinoic acid AKSci J10054
 
 
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  J10054    
Retinoic acid
, 99% (HPLC)
 
ATRA
Tretinoin
Vitamin A acid
more..




IDENTITY
CAS Number:[302-79-4]
MDL Number:MFCD00001551
MF:C20H28O2
MW:300.44
EINECS:206-129-0
BRN:2057223
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Available Spectra:NMR, HPLC, LCMS
Physical Form:Yellow powder
Melting Point:179-185°C
Long-Term Storage:Store long-term at -20°C
UN #:Not hazmat

BIOLOGICAL INFO
Solubility:DMSO: 60mg/mL; H2O: <1mg/mL; EtOH: 6mg/mL
Application(s):Binds to the retinoic acid receptor (RAR)
Form:Free Base

REVIEW

 Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoic acid acts by binding to the retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR) in regions called retinoic acid response elements (RAREs). Binding of the retinoic acid ligand to RAR alters the conformation of the RAR, which affects the binding of other proteins that either induce or repress transcription of a nearby gene (including Hox genes and several other target genes). Retinoic acid receptors mediate transcription of different sets of genes controlling differentiation of a variety of cell types, thus the target genes regulated depend upon the target cells.

REFERENCES
[1]Sheeba CJ, Palmeirim I, Andrade RP (2012). Retinoic acid signaling regulates embryonic clock hairy2 gene expression in the developing chick limb. Biochem Biophys Res Commun. 423(4):889-94. PMID 22728880.
[2] Gulliver WP, Baker KA (2012). Effective treatment of chronic hand dermatitis with 36 continuous months of alitretinoin administration: report of three cases. J Cutan Med Surg. 16(4):267-71. PMID 22784520.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302; H401

Precautionary Statements
P264; P270; P273; P301+P312; P330; P501


RELATED PRODUCTS
F739Isotretinoin
E670Retinoic acid

Current as of March 22, 2017


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CATEGORIES

 APIs and Bioactives > Vitamins


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