REVIEW Sotalol hydrochloride is the salt of sotalol, a racemic phenethanolamine used in individuals with cardiac arrhythmias and to treat hypertension. It is a non-selective competitive beta-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties by its inhibition of potassium channels.
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Lish, P. M.; Weikel, J. H.; Dungan, K. W. Pharmacological and toxicological properties of two new β-adrenergic receptor antagonists Journal of Pharmacology and Experimental Therapeutics (1965), 149(2), 161-73.
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Aviado DM.Sotalol, a pure beta-adrenergic blocking agent for treatment of essential hypertension and other cardiovascular diseases. J Clin Pharmacol. 1979 Aug-Sep;19(8-9 Pt 2):497-504.
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