959-24-0 Sotalol HCl AKSci J10044

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J10044
Sotalol HCl, >98% (HPLC)

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N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride

Sotalex

IDENTITY
CAS Number:	959-24-0
MDL Number:	MFCD00242937
MF:	C12H21ClN2O3S
MW:	308.82
EINECS:	213-496-0

SPECIFICATIONS & PROPERTIES
Purity:	>98% (HPLC)
Spectra:	LCMS, HPLC
Physical Form:	White to off-white crystalline powder to powder
Melting Point:	214-220°C
Long-Term Storage:	Store at room temperature

BIOLOGICAL INFO
Solubility:	DMSO: 62mg/mL; H2O: 20mg/mL; EtOH: <1mg/mL
Application(s):	beta-adrenoceptor antagonist
Form:	HCl salt

REVIEW
Sotalol hydrochloride is the salt of sotalol, a racemic phenethanolamine used in individuals with cardiac arrhythmias and to treat hypertension. It is a non-selective competitive beta-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties by its inhibition of potassium channels.

REFERENCES

[1]	Uloth, Robert H.; Kirk, Jerry R.; Gould, William A.; Larsen, A. A. Sulfonanilides. I. Monoalkane- and arenesulfonamidophenethanolamines Journal of Medicinal Chemistry (1966), 9(1), 88-97.
[2]	Lish, P. M.; Weikel, J. H.; Dungan, K. W. Pharmacological and toxicological properties of two new β-adrenergic receptor antagonists Journal of Pharmacology and Experimental Therapeutics (1965), 149(2), 161-73.
[3]	Schnelle K Clinical pharmacology of adrenergic beta receptor blockade with sotalol (MJ 1999). Adv Clin Pharmacol. 1978;18:1-111.
[4]	Aviado DM.Sotalol, a pure beta-adrenergic blocking agent for treatment of essential hypertension and other cardiovascular diseases. J Clin Pharmacol. 1979 Aug-Sep;19(8-9 Pt 2):497-504.