959-24-0 Sotalol HCl AKSci J10044
 
 
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  J10044    AKSci Reference Standard
Sotalol HCl, >98% (HPLC), powder
 
N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride
Sotalex
IDENTITY
CAS Number:959-24-0
MDL Number:MFCD00242937
MF:C12H21ClN2O3S
MW:308.82
EINECS:213-496-0
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Spectra:LCMS, HPLC
Physical Form (at 20°C):White to off-white crystalline powder to powder
Melting Point:214-220°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 62mg/mL; H2O: 20mg/mL; EtOH: <1mg/mL
Application(s):beta-adrenoceptor antagonist
Form:HCl salt

REVIEW
 Sotalol hydrochloride is the salt of sotalol, a racemic phenethanolamine used in individuals with cardiac arrhythmias and to treat hypertension. It is a non-selective competitive beta-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties by its inhibition of potassium channels.

REFERENCES
[1]Uloth, Robert H.; Kirk, Jerry R.; Gould, William A.; Larsen, A. A. Sulfonanilides. I. Monoalkane- and arenesulfonamidophenethanolamines Journal of Medicinal Chemistry (1966), 9(1), 88-97.
[2] Lish, P. M.; Weikel, J. H.; Dungan, K. W. Pharmacological and toxicological properties of two new β-adrenergic receptor antagonists Journal of Pharmacology and Experimental Therapeutics (1965), 149(2), 161-73.
[3] Schnelle K Clinical pharmacology of adrenergic beta receptor blockade with sotalol (MJ 1999). Adv Clin Pharmacol. 1978;18:1-111.
[4] Aviado DM.Sotalol, a pure beta-adrenergic blocking agent for treatment of essential hypertension and other cardiovascular diseases. J Clin Pharmacol. 1979 Aug-Sep;19(8-9 Pt 2):497-504.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
E923Sotalol
H026Sotalol HCl

Current as of January 25, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Arrhythmia, Beta Blockers


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