79794-75-5 Loratadine AKSci J10034
 
 
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  J10034    AKSci Reference Standard
Loratadine
, 99% (HPLC)
 
Alavert
Claritin
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester




IDENTITY
CAS Number:79794-75-5
MDL Number:MFCD00672869
MF:C22H23ClN2O2
MW:382.88
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:132-139°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 50mg/mL; H2O: insoluble; EtOH: 77mg/mL
Application(s):Histamine H1-receptor antagonist
Form:Free Base

REVIEW

 Loratadine is a tricyclic antihistamine, which acts as a selective inverse agonist of peripheral histamine H1-receptors.

REFERENCES
[1]Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W (2011). Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 7(12):e1002310. PMID 22194678.
[2] M?sges R, K?nig V, K?berlein J (2011). The effectiveness of levocetirizine in comparison with loratadine in treatment of allergic rhinitis--a meta-analysis. Allergol Int. 60(4):541-6. PMID 21918368.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of April 15, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antihistamines


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