10238-21-8 Glyburide AKSci J10021
 
 
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  J10021    
Glyburide, 99% (HPLC)
 
Glibenclamide
IDENTITY
CAS Number:10238-21-8
MDL Number:MFCD00056625
MF:C23H28ClN3O5S
MW:494
EINECS:233-570-6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:171-176°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 99mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Hypoglycemic Agent; Sulfonylurea receptor 1 (SUR1) Inhibitor
Form:Free Base

REVIEW
 An antidiabetic drug in a class of medications known as sulfonylureas. The drug works by inhibiting the sulfonylurea receptor 1 (SUR1), the regulatory subunit of the ATP-sensitive potassium channels (KATP)[2] in pancreatic beta cells. This inhibition causes cell membrane depolarization opening voltage-dependent calcium channel. This results in an increase in intracellular calcium in the beta cell and subsequent stimulation of insulin release.

REFERENCES
[1]Nguyen KH, Ta TN, Pham TH, Nguyen QT, Pham HD, Mishra S, Nyomba BL (2012). Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide. J Ethnopharmacol. 142(2):488-95. PMID 22633982.
[2] Yamauchi K, Stone AJ, Stocker SD, Kaufman MP (2012). Blockade of ATP-sensitive potassium channels prevents the attenuation of the exercise pressor reflex by tempol in rats with ligated femoral arteries. Am J Physiol Heart Circ Physiol. 303(3):H332-40. PMID 22636679.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of February 1, 2025


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CATEGORIES
 APIs and Bioactives > Diabetes


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