An apoptosis inducer via PKC-dependent signalling pathway
REVIEW A bile acid. When the compound is altered by bacteria in the colon, it will result in conversion to its secondary bile acid known as lithocholic acid. Both of these bile acids, in addition to the others, can be conjugated to taurine or glycine. Conjugation, a function carried out by the liver will result in a lowered pKa and therefore, the compounds will remain ionized. These ionized compounds will stay in the gastrointestinal tract until reaching the ileum where they will be reabsorbed. The purpose of this conjugation is to keep the bile acids in the tract until the end to facilitate lipid digestion all the way to the ileum.
Casaburi I, Avena P, Lanzino M, Sisci D, Giordano F, Maris P, Catalano S, Morelli C, Andò S (2012). Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 11(14):2699-710. PMID 22751440.
Liu CL, Chang CL, Jhou SY, Higuchi WI (2012). Determination of binding affinity for chenodeoxycholate in equilibrium with sulfobutylether-beta-cyclodextrin. J Pharm Sci. 101(8):2883-90. PMID 22674230.
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