474-25-9 Chenodeoxycholic acid AKSci J10019
 
 
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  J10019    AKSci Reference Standard
Chenodeoxycholic acid
, >98% (HPLC), powder
 
3alpha,7alpha-Dihydroxy-5beta-cholanic acid, 5beta-Cholanic acid-3alpha,7alpha-diol
Chenodiol
Chenocholic acid




IDENTITY
CAS Number:474-25-9
MDL Number:MFCD00064142
MF:C24H40O4
MW:392.57
EINECS:207-481-8
BRN:3219887
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC), powder
Spectra:NMR, FT-IR, LCMS, HPLC, Polarimetry
Physical Form:White to light yellow crystalline powder
Melting Point:142-146°C
Optical Rotation:+13° (c=2, EtOH)
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: 79mg/mL; H2O: <1mg/mL; EtOH: 79mg/mL
Application(s):An apoptosis inducer via PKC-dependent signalling pathway
Form:Free Base

REVIEW

 A bile acid. When the compound is altered by bacteria in the colon, it will result in conversion to its secondary bile acid known as lithocholic acid. Both of these bile acids, in addition to the others, can be conjugated to taurine or glycine. Conjugation, a function carried out by the liver will result in a lowered pKa and therefore, the compounds will remain ionized. These ionized compounds will stay in the gastrointestinal tract until reaching the ileum where they will be reabsorbed. The purpose of this conjugation is to keep the bile acids in the tract until the end to facilitate lipid digestion all the way to the ileum.

REFERENCES
[1]Casaburi I, Avena P, Lanzino M, Sisci D, Giordano F, Maris P, Catalano S, Morelli C, Andò S (2012). Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 11(14):2699-710. PMID 22751440.
[2] Liu CL, Chang CL, Jhou SY, Higuchi WI (2012). Determination of binding affinity for chenodeoxycholate in equilibrium with sulfobutylether-beta-cyclodextrin. J Pharm Sci. 101(8):2883-90. PMID 22674230.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 7, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.

WARNING: Attention California residents: This product can expose you to chemicals including Chenodeoxycholic acid, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES

 APIs and Bioactives > Bile Acids


PubChem