59-42-7, 614-03-9 L-Phenylephrine AKSci J10016
 
 
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  J10016    AKSci Reference Standard
L-Phenylephrine
, >98% (HPLC), powder
 



IDENTITY
CAS Number:59-42-7, 614-03-9
MDL Number:MFCD00044749
MF:C9H13NO2
MW:167.21
EINECS:200-424-8
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:170-174°C
Optical Rotation:-52 ~ -58° (c=5, 1mol/L HCl)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Hot Methanol
Application(s):Alpha-1-adrenergic receptor agonist

REVIEW

 In general, alpha1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. alpha1-receptors are 7-transmembrane domain receptors coupled to G proteins, Gq/11. Three alpha1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: alpha1A (chromosome 8), alpha1B (chromosome 5), and alpha1D (chromosome 20). Phenylephrine appears to act similarly on all three receptor subtypes. All three receptor subtypes appear to be involved in maintaining vascular tone. The alpha1A-receptor maintains basal vascular tone while the alpha1B-receptor mediates the vasocontrictory effects of exogenous alpha1-agonists. Activation of the alpha1-receptor activates Gq-proteins, which results in intracellular stimulation of phospholipases C, A2, and D. This results in mobilization of Ca2+ from intracellular stores, activation of mitogen-activated kinase and PI3 kinase pathways and subsequent vasoconstriction. Phenylephrine produces its local and systemic actions by acting on alpha1-adrenergic receptors peripheral vascular smooth muscle. Stimulation of the alpha1-adrenergic receptors results in contraction arteriolar smooth muscle in the periphery. Phenylephrine decreases nasal congestion by acting on alpha1-adrenergic receptors in the arterioles of the nasal mucosa to produce constriction; this leads to decreased edema and increased drainage of the sinus cavities.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of October 2, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Adrenergic Agonists


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