137862-53-4 Valsartan AKSci J10013
 
 
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  J10013    
Valsartan
, >98% (HPLC)
 
Camptothecin, N-(1-Oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine




IDENTITY
CAS Number:137862-53-4
MDL Number:MFCD00865840
MF:C24H29N5O3
MW:435.52
EINECS:604-045-2
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:LCMS, HPLC, Polarimetry
Physical Form:White to off-white to tan crystalline powder or powder
Melting Point:97-107°C
Optical Rotation:-55.0° - -70.0° (c=1, MeOH)
Long-Term Storage:Store long-term at 2-8°C
UN #:Not hazmat

BIOLOGICAL INFO
Solubility:DMSO: =20mg/mL; MeOH; EtOH
Application(s):Angiotensin II receptor antagonist
Form:Free Base

REVIEW

 Valsartan is an ARB that selectively inhibits the binding of angiotensin II to AT1, which is found in many tissues such as vascular smooth muscle and the adrenal glands. This effectively inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects of angiotensin II and results in a decrease in vascular resistance and blood pressure. Valsartan is selective for AT1 and has virtually no affinity for AT2. Inhibition of aldosterone secretion may inhibit sodium and water reabsorption in the kidneys while decreasing potassium excretion. The primary metabolite of valsartan, valeryl 4-hydroxy valsartan, has no pharmacological activity.

REFERENCES
[1]Bader, M. (2004). Renin-angiotensin-aldosterone system. In S. Offermanns, & W. Rosenthal (Eds.). Encyclopedic reference of molecular pharmacology (pp. 810-814). Berlin, Germany: Springer.
[2] Stanfield, C.L., & Germann, W.J. (2008). Principles of human physiology (3 rd ed.). San Francisco, CA: Pearson Education, Inc.

GHS


Signal Word
None

Hazard Statements
H413

Precautionary Statements
P273; P501


Current as of January 18, 2019


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CATEGORIES

 APIs and Bioactives > Angiotensin Receptor Blockers


PubChem