7689-03-4 (S)-(+)-Camptothecin AKSci J10012
 
 
Loading Please Wait...
  J10012    AKSci Reference Standard
(S)-(+)-Camptothecin
, >98% (HPLC), powder
 
Camptothecin




IDENTITY
CAS Number:7689-03-4
MDL Number:MFCD00081076
MF:C20H16N2O4
MW:348.35
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Spectra:NMR, LCMS, FT-IR, HPLC, Polarimetry
Physical Form:Yellow to yellow-brown powder
Melting Point:271-279°C
Optical Rotation:+37° - +42° (c=0.4, CHCl3:MeOH=8:2)
Long-Term Storage:Store long-term at 2-8°C
HAZARDOUS MATERIALS INFORMATION
UN #:UN1544
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply, depending on the amount ordered.

BIOLOGICAL INFO
Solubility:DMSO: 3mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL; CHCl3/MeOHl (4:1): 4mg/mL
Application(s):DNA Topoisomerase I Inhibitor
Form:Free Base

REVIEW

 Camptothecin binds to the topoisomerase I and DNA complex (the covalent complex) resulting in a ternary complex, and thereby stabilizing it. This prevents DNA relegation and therefore causes DNA damage which results in apoptosis.

REFERENCES
[1]Wall ME, Wani MC: Camptothecin and taxol: from discovery to clinic. J Ethnopharmacol. 1996 Apr;51(1-3):239-53; discussion 253-4.
[2] Kepler JA, Wani MC, McNaull JN, Wall ME, Levine SG: Plant antitumor agents. IV. An approach toward the synthesis of camptothecin. J Org Chem. 1969 Dec;34(12):3853-8.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501


Current as of April 21, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.


CATEGORIES

 APIs and Bioactives > Chemotherapeutics


PubChem