7689-03-4 (S)-(+)-Camptothecin AKSci J10012
 
 
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  J10012    AKSci Reference Standard
(S)-(+)-Camptothecin, >98% (HPLC), powder
 
Camptothecin
IDENTITY
CAS Number:7689-03-4
MDL Number:MFCD00081076
MF:C20H16N2O4
MW:348.35
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Spectra:NMR, LCMS, FT-IR, HPLC, Polarimetry
Physical Form:Yellow to yellow-brown powder
Melting Point:271-279°C
Optical Rotation:+37° - +42° (c=0.4, CHCl3:MeOH=8:2)
Long-Term Storage:Store long-term at 2-8°C
HAZARDOUS MATERIALS INFORMATION
UN #:UN1544
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply, depending on the amount ordered.

BIOLOGICAL INFO
Solubility:DMSO: 3mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL; CHCl3/MeOHl (4:1): 4mg/mL
Application(s):DNA Topoisomerase I Inhibitor
Form:Free Base

REVIEW
 Camptothecin binds to the topoisomerase I and DNA complex (the covalent complex) resulting in a ternary complex, and thereby stabilizing it. This prevents DNA relegation and therefore causes DNA damage which results in apoptosis.

REFERENCES
[1]Wall ME, Wani MC: Camptothecin and taxol: from discovery to clinic. J Ethnopharmacol. 1996 Apr;51(1-3):239-53; discussion 253-4.
[2] Kepler JA, Wani MC, McNaull JN, Wall ME, Levine SG: Plant antitumor agents. IV. An approach toward the synthesis of camptothecin. J Org Chem. 1969 Dec;34(12):3853-8.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of April 21, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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