54-31-9 Furosemide AKSci J10011
 
 
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  J10011    
Furosemide, 99% (HPLC), powder
 
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid
5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Frusemide
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IDENTITY
CAS Number:54-31-9
MDL Number:MFCD00010549
MF:C12H11ClN2O5S
MW:330.74
EINECS:200-203-6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:218-220°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 66mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Sodium Potassium Chloride Symporter Inhibitor
Form:Free Base

REVIEW
 A loop diuretic used in the treatment of congestive heart failure and edema. Furosemide acts by inhibiting NKCC2, the luminal Na-K-2Cl symporter in the thick ascending limb of the loop of Henle.

REFERENCES
[1]Hochman DW (2012). The extracellular space and epileptic activity in the adult brain: explaining the antiepileptic effects of furosemide and bumetanide. Epilepsia. 53 Suppl 1:18-25. PMID 22612805.
[2] Sigmund EE, Vivier PH, Sui D, Lamparello NA, Tantillo K, Mikheev A, Rusinek H, Babb JS, Storey P, Lee VS, Chandarana H (2012). Intravoxel incoherent motion and diffusion-tensor imaging in renal tissue under hydration and furosemide flow challenges. Radiology. 263(3):758-69. PMID 22523327.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H360

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501

Current as of October 11, 2024


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CATEGORIES
 APIs and Bioactives > Diuretics


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