29122-68-7 Atenolol AKSci J10009

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J10009 AKSci Reference Standard
Atenolol, >98% (HPLC)

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2-[4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl]acetamide

IDENTITY
CAS Number:	29122-68-7
MDL Number:	MFCD00057645
MF:	C14H22N2O3
MW:	266.34
EINECS:	249-451-7

SPECIFICATIONS & PROPERTIES
Purity:	>98% (HPLC)
Spectra:	NMR, LCMS, HPLC
Physical Form:	White to off-white powder
Melting Point:	146-148°C
Long-Term Storage:	Store at room temperature

BIOLOGICAL INFO
Solubility:	DMSO; ethanol; H2O; DMSO
Application(s):	beta-Adrenergic blocker

REVIEW
Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.

REFERENCES

[1]	Agon P, Goethals P, Van Haver D, Kaufman JM (August 1991). Permeability of the blood-brain barrier for atenolol studied by positron emission tomography. J. Pharm. Pharmacol. 43 (8): 597-600. doi:10.1111/j.2042-7158.1991.tb03545.x. PMID 1681079.
[2]	Carlberg B, Samuelsson O, Lindholm LH (2004). Atenolol in hypertension: is it a wise choice?. Lancet 364 (9446): 1684-9. doi:10.1016/S0140-6736(04)17355-8. PMID 15530629.

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