29122-68-7 Atenolol AKSci J10009
 
 
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  J10009    AKSci Reference Standard
Atenolol, >98% (HPLC)
 
2-[4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl]acetamide
IDENTITY
CAS Number:29122-68-7
MDL Number:MFCD00057645
MF:C14H22N2O3
MW:266.34
EINECS:249-451-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Spectra:NMR, LCMS, HPLC
Physical Form (at 20°C):White to off-white powder
Melting Point:146-148°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO; ethanol; H2O; DMSO
Application(s):beta-Adrenergic blocker

REVIEW
 Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.

REFERENCES
[1]Agon P, Goethals P, Van Haver D, Kaufman JM (August 1991). Permeability of the blood-brain barrier for atenolol studied by positron emission tomography. J. Pharm. Pharmacol. 43 (8): 597-600. doi:10.1111/j.2042-7158.1991.tb03545.x. PMID 1681079.
[2] Carlberg B, Samuelsson O, Lindholm LH (2004). Atenolol in hypertension: is it a wise choice?. Lancet 364 (9446): 1684-9. doi:10.1016/S0140-6736(04)17355-8. PMID 15530629.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 25, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.

WARNING: Attention California residents: This product can expose you to chemicals including Atenolol, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES
 APIs and Bioactives > Beta Blockers


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