29122-68-7 Atenolol AKSci J10009
 
 
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  J10009    AKSci Reference Standard
Atenolol
, >98% (HPLC)
 
2-[4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl]acetamide




IDENTITY
CAS Number:29122-68-7
MDL Number:MFCD00057645
MF:C14H22N2O3
MW:266.34
EINECS:249-451-7
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:NMR, LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:146-148°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO; ethanol; H2O; DMSO
Application(s):beta-Adrenergic blocker

REVIEW

 Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.

REFERENCES
[1]Agon P, Goethals P, Van Haver D, Kaufman JM (August 1991). Permeability of the blood-brain barrier for atenolol studied by positron emission tomography. J. Pharm. Pharmacol. 43 (8): 597-600. doi:10.1111/j.2042-7158.1991.tb03545.x. PMID 1681079.
[2] Carlberg B, Samuelsson O, Lindholm LH (2004). Atenolol in hypertension: is it a wise choice?. Lancet 364 (9446): 1684-9. doi:10.1016/S0140-6736(04)17355-8. PMID 15530629.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of June 25, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Beta Blockers


PubChem