29122-68-7, 60966-51-0; 56715-13-0 Atenolol AKSci J10009
 
 
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  J10009    AKSci Reference Standard
Atenolol
, >98% (HPLC)
 
2-[4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl]acetamide




IDENTITY
CAS Number:29122-68-7, 60966-51-0; 56715-13-0
MDL Number:MFCD00057645
MF:C14H22N2O3
MW:266.34
EINECS:249-451-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:146-148°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO; ethanol; H2O; DMSO
Application(s):beta-Adrenergic blocker

REVIEW

 Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.

REFERENCES
[1]Agon P, Goethals P, Van Haver D, Kaufman JM (August 1991). Permeability of the blood-brain barrier for atenolol studied by positron emission tomography. J. Pharm. Pharmacol. 43 (8): 597-600. doi:10.1111/j.2042-7158.1991.tb03545.x. PMID 1681079.
[2] Carlberg B, Samuelsson O, Lindholm LH (2004). Atenolol in hypertension: is it a wise choice?. Lancet 364 (9446): 1684-9. doi:10.1016/S0140-6736(04)17355-8. PMID 15530629.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 1, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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⚠️
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Atenolol, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.



CATEGORIES

 APIs and Bioactives > Beta Blockers


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