29122-68-7 Atenolol AKSci J10009
 
 
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  J10009    AKSci Reference Standard
Atenolol
, >98% (HPLC)
 
2-[4-(2-Hydroxy-3-isopropylaminopropoxy)phenyl]acetamide




IDENTITY
CAS Number:29122-68-7
MDL Number:MFCD00057645
MF:C14H22N2O3
MW:266.34
EINECS:249-451-7
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:NMR, LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:146-148°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO; ethanol; H2O; DMSO
Application(s):beta-Adrenergic blocker

REVIEW

 Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.

REFERENCES
[1]Agon P, Goethals P, Van Haver D, Kaufman JM (August 1991). Permeability of the blood-brain barrier for atenolol studied by positron emission tomography. J. Pharm. Pharmacol. 43 (8): 597-600. doi:10.1111/j.2042-7158.1991.tb03545.x. PMID 1681079.
[2] Carlberg B, Samuelsson O, Lindholm LH (2004). Atenolol in hypertension: is it a wise choice?. Lancet 364 (9446): 1684-9. doi:10.1016/S0140-6736(04)17355-8. PMID 15530629.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 17, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use.
Not for human use.

WARNING: Attention California residents: This product can expose you to chemicals including Atenolol, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES

 APIs and Bioactives > Beta Blockers


PubChem