318-98-9 (+/-)-Propranolol HCl AKSci J10004
 
 
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  J10004    AKSci Reference Standard
(+/-)-Propranolol HCl, 99% (HPLC), powder
 
Propanolol hydrochloride
1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride
IDENTITY
CAS Number:318-98-9
MDL Number:MFCD00012558
MF:C16H22ClNO2
MW:295.8
EINECS:206-268-7
BRN:4164259
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Spectra:NMR, FT-IR, LCMS, HPLC
Physical Form (at 20°C):White to off-white powder
Melting Point:159-168°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:EtOH: 10mg/mL;DMSO: <14.5mg/mL; H2O: 50mg/mL 10mg/0.5mL; DCM: undissolved material; 0.5mL MeOH: Cloudy solution
Application(s):beta-Adrenergic antagonist
Form:HCl salt

REVIEW
 Propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.

REFERENCES
[1]Brunet A, Orr SP, Tremblay J, Robertson K, Nader K, Pitman RK: Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J Psychiatr Res. 2007 Jun 21;.
[2] Ohnishi ST, Sadanaga KK, Katsuoka M, Weidanz WP: Effects of membrane acting-drugs on plasmodium species and sickle cell erythrocytes. Mol Cell Biochem. 1989 Nov 23-Dec 19;91(1-2):159-65.
[3] Singh N, Puri SK: Interaction between chloroquine and diverse pharmacological agents in chloroquine resistant Plasmodium yoelii nigeriensis. Acta Trop. 2000 Nov 2;77(2):185-93.
[4] Murphy SC, Harrison T, Hamm HE, Lomasney JW, Mohandas N, Haldar K: Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS Med. 2006 Dec;3(12):e528.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of January 25, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Beta Blockers


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