138402-10-5 Triphenyl irbesartan AKSci I998
 
 
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  I998    AKSci Bulk Reagent
Triphenyl irbesartan, 98%
 



IDENTITY
CAS Number:138402-10-5
MDL Number:MFCD08460099
MF:C44H42N6O
MW:670.84
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:142-148°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Triphenyl irbesartan is an advanced intermediate used in the preparation of irbesartan, an angiotension II antagonist, used in the treatment of hypertension.

REFERENCES
[1]Bernhart, Claude; Breliere, Jean Claude; Clement, Jacques; Nisato, Dino; Perreaut, Pierre; Preparation of N-(carboxybiphenylylmethyl)spiro[cycloalkane-imidazolinone] derivatives and analogs as angiotensin II inhibitors. PCT Int. Appl. (1991), WO 9114679 A1 19911003.
[2] Spinale, Francis Guy; N-substituted spirocyclopentaneimidazolinone derivatives for the treatment or prevention of cardiac arrhythmia. Can. Pat. Appl. (1996), CA 2154807 A1 19960223.
[3] Castro, Bertrand; Dormoy, Jean-Robert; Mach, Mateusz; Makosza, Mieczyslaw; Pankowski, Jacek; Preparation of 2-oxazolinyl-4'-phthalimidomethylbiphenyls. PCT Int. Appl. (1999), WO 9906398 A1 19990211.
[4] Nisnevich, Gennady; Rukhman, Igor; Pertsikov, Boris; Kaftanov, Julia; Dolitzky, Ben-Zion; Shapiro, Eugeny; Yahalomi, Bonit; Synthesis of irbesartan. PCT Int. Appl. (2004), WO 2004007482 A2 20040122.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of March 26, 2023


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CATEGORIES
 APIs and Bioactives > Angiotensin Receptor Blockers, Hypertension


PubChem
  @PubMed