103890-78-4 Lacidipine AKSci I788
 
 
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  I788    
Lacidipine
, 98%
 



IDENTITY
CAS Number:103890-78-4
MDL Number:MFCD00865936
MF:C26H33NO6
MW:455.54
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:Off white to light yellow powder
Melting Point:174-175°C
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Application(s):L-type calcium channel blocker

REVIEW

 Lacidipine is a dihydropyridine calcium channel blocker antagonist for the treatment of hypertension. It has a high membrane partition coefficient compared to other 1,4-dihydropyridine calcium-channel antagonists and a slow washout rate from membranes. Clinically, it also exhibits an extended duration of action.

REFERENCES
[1]Semeraro, Claudio; Micheli, Dino; Pieraccioli, Daniele; Gaviraghi, Giovanni; Borthwick, Allan David 4-Phenyl-1,4-dihydropyridinecarboxylic acid esters Ger. Offen. (1986), DE 3529997 A1 19860306.
[2] Pieraccioli, Daniele Esterification of (carboxyethenylphenyl)dihydropyridines using amide acetals Eur. Pat. Appl. (1990), EP 370974 A2 19900530.
[3] Sajja, Eswaraiah; Vetukuri, Venkata Naga Kali Vara Prasada Raju; Ningam, Srinivas Reddy; Vedantham, Ravindra Process for preparing lacidipine U.S. Pat. Appl. Publ. (2007), US 20070043088 A1 20070222.
[4] Micheli D, Ratti E, Toson G, Gaviraghi G. Pharmacology of lacidipine, a vascular-selective calcium antagonist. J Cardiovasc Pharmacol. 1991;17 Suppl 4:S1-8.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of July 7, 2020


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CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers


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