86639-52-3 7-Ethyl-10-hydroxycamptothecin AKSci I605
 
 
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  I605    AKSci Reference Standard
7-Ethyl-10-hydroxycamptothecin
, 99% (HPLC), powder
 
SN-38




IDENTITY
CAS Number:86639-52-3
MDL Number:MFCD00871873
MF:C22H20N2O5
MW:392.41
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Spectra:FT-IR, LCMS, HPLC
Physical Form:Off-white to yellow crystalline powder or powder
Long-Term Storage:Store long-term at -20°C
HAZARDOUS MATERIALS INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply, depending on the amount ordered.

REVIEW

 7-Ethyl-10-hydroxy camptothecin is a topoisomerase I inhibitor and is the active metabolite of irinotecan, its prodrug. It is approximately 100- to 1000-fold more cytotoxic than the parent drug. Irinotecan has shown a broad spectrum of antitumor activity in preclinical models as well as clinically, with responses observed in various disease types including colorectal, lung, cervical, and ovarian cancer.

REFERENCES
[1]Yu, Shanbao; Huang, Qing-Qing; Luo, Yu; Lu, Wei Total Synthesis of Camptothecin and SN-38 Journal of Organic Chemistry (2012), 77(1), 713-717.
[2] Yao, Yuan-Shan; Liu, Jia-Li; Xi, Jie; Miu, Bukeyan; Liu, Guai-Sai; Wang, Shaozhong; Meng, Linghua; Yao, Zhu-Jun Total Synthesis of 7-Ethyl-10-hydroxycamptothecin (SN38) and its Application to the Development of C18-Functionalized Camptothecin Derivatives Chemistry - A European Journal (2011), 17(37), 10462-10469, S10462/1-S10462/92.
[3] Kuang, Yun-Yan; Niu, Jing-Ze; Chen, Fen-Er Synthetic Studies on Camptothecins. Part 3 Total Synthesis of (20S)-7-Ethyl-10-hydroxycamptothecin via a Bifunctional Thiourea-Based Cinchona Alkaloid-Mediated Enantioselective Cyanosilylation Strategy Helvetica Chimica Acta (2010), 93(10), 2094-2099.
[4] Rivory LP.Irinotecan (CPT-11): a brief overview. Clin Exp Pharmacol Physiol. 1996 Oct-Nov;23(10-11):1000-4.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501


Current as of April 22, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Chemotherapeutics


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