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REVIEW 7-Ethyl-10-hydroxy camptothecin is a topoisomerase I inhibitor and is the active metabolite of irinotecan, its prodrug. It is approximately 100- to 1000-fold more cytotoxic than the parent drug. Irinotecan has shown a broad spectrum of antitumor activity in preclinical models as well as clinically, with responses observed in various disease types including colorectal, lung, cervical, and ovarian cancer.
Yu, Shanbao; Huang, Qing-Qing; Luo, Yu; Lu, Wei Total Synthesis of Camptothecin and SN-38 Journal of Organic Chemistry (2012), 77(1), 713-717.
Yao, Yuan-Shan; Liu, Jia-Li; Xi, Jie; Miu, Bukeyan; Liu, Guai-Sai; Wang, Shaozhong; Meng, Linghua; Yao, Zhu-Jun Total Synthesis of 7-Ethyl-10-hydroxycamptothecin (SN38) and its Application to the Development of C18-Functionalized Camptothecin Derivatives Chemistry - A European Journal (2011), 17(37), 10462-10469, S10462/1-S10462/92.
Kuang, Yun-Yan; Niu, Jing-Ze; Chen, Fen-Er Synthetic Studies on Camptothecins. Part 3 Total Synthesis of (20S)-7-Ethyl-10-hydroxycamptothecin via a Bifunctional Thiourea-Based Cinchona Alkaloid-Mediated Enantioselective Cyanosilylation Strategy Helvetica Chimica Acta (2010), 93(10), 2094-2099.
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