REVIEW Orbifloxacin (Orbax, Schering-Plough Animal Health) is a broad-spectrum fluoroquinolone antibiotic. Its mechanism of action is to inhibit bacterial DNA gyrase and prevent DNA supercoiling and synthesis.. The compound is approved for use in dogs for the treatment of urinary tract infections (cystitis) caused by susceptible strains of Staphylococcus pseudintermedius, Proteus mirabilis, Escherichia coli and Enterococcus faecalis. Orbifloxacin as an oral suspension is also indicated for skin and soft tissue infections in dogs caused by susceptible strains of Staphylococcus pseudintermedius, Staphylococcus aureus, coagulase positive staphylococci, Pasteurella multocida, Proteus mirabilis, Pseudomonas spp., Klebsiella pneumoniae, Escherichia coli, Enterobacter spp., Citrobacter spp., Enterococcus faecalis, β-hemolytic streptococci (Group G) and Streptococcus equisimilis.
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