106463-17-6 Tamsulosin HCl AKSci H991
 
 
Loading Please Wait...
  H991    
Tamsulosin HCl
, 98% (HPLC)
 
5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
Harnal
Flomax
more..




IDENTITY
CAS Number:106463-17-6
MDL Number:MFCD00922997
MF:C20H29ClN2O5S
MW:444.97
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:LCMS, HPLC, Polarimetry
Physical Form:White to light yellow crystalline powder
Melting Point:227-233°C
Optical Rotation:-17.5° - -20.5° (c=1, H2O)
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: >10mg/mL
Application(s):Selective antagonist at alpha-1A and alpha-1B-adrenoceptors
Form:HCl salt

REVIEW

 Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men.

REFERENCES
[1]Dunn CJ, Matheson A, Faulds DM: Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms. Drugs Aging. 2002;19(2):135-61.
[2] Lyseng-Williamson KA, Jarvis B, Wagstaff AJ: Tamsulosin: an update of its role in the management of lower urinary tract symptoms. Drugs. 2002;62(1):135-67.
[3] Wilt TJ, Mac Donald R, Rutks I: Tamsulosin for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2003;(1):CD002081.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 8, 2020


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.


CATEGORIES

 APIs and Bioactives > Alpha Blockers


PubChem