53179-13-8 Pirfenidone AKSci H960
 
 
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  H960    
Pirfenidone
, 99% (HPLC)
 
5-Methyl-1-phenyl-2-pyridone
5-Methyl-1-phenyl-2-(1H)-pyridone
5-Methyl-1-phenylpyridin-2(1H)-one
more..




IDENTITY
CAS Number:53179-13-8
MDL Number:MFCD00866047
MF:C12H11NO
MW:185.22
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Spectra:LCMS, FT-IR, HPLC
Physical Form:White to light yellow crystalline powder
Melting Point:107-111°C
Long-Term Storage:Store long-term at -20°C
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >20 mg/mL, H2O: >10 mg/mL at 60 °C (warming for 30 minutes)
Application(s):Anti-Inflammatory Agent; Antineoplastic Agent; Inhibits TGF-beta stimulated collagen production
Form:Free Base

REVIEW

 Pirfenidone is an orally active synthetic antifibrotic agent and an immunosuppressant that used for the treatment of idiopathic pulmonary fibrosis. It inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. used for the treatment of idiopathic pulmonary fibrosis.

REFERENCES
[1]Lee B S; Margolin S B; Nowak R A. Pirfenidone: a novel pharmacological agent that inhibits leiomyoma cell proliferation and collagen production. The Journal of Clinical Endocrinology and Metabolism. (1998) 83(1): 219-23.
[2] Dosanjh Amrita. Pirfenidone: anti-fibrotic agent with a potential therapeutic role in the management of transplantation patients. European Journal of Pharmacology. (2006) 536(3): 219-22.
[3] Antoniu, Sabina A. Pirfenidone for the treatment of idiopathic pulmonary fibrosis. Expert Opinion on Investigational Drugs. (2006) 15(7): 823-828.
[4] Gadekar, Shreekrishna M.Analgesic 1-substituted pyridones Ger. Offen. (1974), DE 2362958 A1 19740627

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P270; P264; P301+P312+P330; P330; P501;


Current as of February 27, 2021


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