7081-53-0 Doxapram HCl AKSci H927
 
 
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  H927    AKSci Reference Standard
Doxapram HCl, 98% (HPLC)
 
3,3-Diphenyl-1-ethyl-4-(2-morpholinoethyl)-2-pyrrolidinone hydrochloride
IDENTITY
CAS Number:7081-53-0
MDL Number:MFCD00072148
MF:C24H30N2O2.HCl
MW:414.97
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:217-219°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Application(s):Central Nervous System Stimulant; Respiratory System Agent
Form:HCl salt

REVIEW
 Doxapram HCl is an analeptic agent (a stimulant of the central nervous system), a central respiratory stimulant with a brief duration of action. It produces respiratory stimulation mediated through the peripheral carotid chemoreceptors. Therefore, it is used in intensive care settings to stimulate the respiratory rate in patients with respiratory failure.

REFERENCES
[1]Boutroy, Marie-Jeanne. Pharmacology and use of methylxanthines and doxapram for the treatment of neonatal apnea. Edited by Jacqz-Aigrain; Choonara, Imti. Paediatric Clinical Pharmacology. (2006) 417-423.
[2] Yost CS. A new look at the respiratory stimulant doxapram. CNS Drug Rev. (2006) Fall-Winter;12(3-4): 236-49.
[3] Bhatia J. Current options in the management of apnea of prematurity. Clinical pediatrics. (2000) 39(6): 327-36.
[4] Lunsford, Carl D.; Cale, Albert D., Jr.4-(omega-Substituted alkyl)-3,3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3,3-disubstituted-1-substituted-2-pyrrolidinethiones (1965), US 3192221 19650629

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 20, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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