10592-13-9 Doxycycline HCl AKSci H909
 
 
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  H909    
Doxycycline HCl
, 97%
 



IDENTITY
CAS Number:10592-13-9
MDL Number:MFCD03427564
MF:C22H24N2O8.HCl
MW:480.90
EINECS:234-198-7
SPECIFICATIONS & PROPERTIES
Purity:97%
Spectra:LCMS, HPLC
Physical Form:Yellow crystalline powder
Melting Point:219-225°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Application(s):Antibiotic
Form:HCl salt

REVIEW

 Doxycycline, like minocycline, is lipophilic and can pass through the lipid bilayer of bacteria. Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial protein synthesis. Doxycycline prevents the normal function of the apicoplast of Plasmodium falciparum, a malaria causing organism.

REFERENCES
[1]Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, Rosenthal PJ: Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep;50(9):3124-31.
[2] Hoerauf A, Mand S, Fischer K, Kruppa T, Marfo-Debrekyei Y, Debrah AY, Pfarr KM, Adjei O, Buttner DW: Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol. 2003 Nov;192(4):211-6. Epub 2003 Mar 5.
[3] Taylor MJ, Makunde WH, McGarry HF, Turner JD, Mand S, Hoerauf A: Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. Lancet. 2005 Jun 18-24;365(9477):2116-21.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of June 18, 2019


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CATEGORIES

 APIs and Bioactives > Antibacterials, Antimalarials, Antiparasitics, Tetracyclines


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