643-22-1 Erythromycin stearate, >550ug/mg AKSci H893
 
 
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  H893    AKSci Bulk Reagent
Erythromycin stearate, >550ug/mg
 



IDENTITY
CAS Number:643-22-1
MDL Number:MFCD00084690
MF:C37H67NO13.C18H36O2
MW:1018.40
EINECS:211-396-1
SPECIFICATIONS & PROPERTIES
Physical Form (at 20°C):Solid
Melting Point:100-104°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Antibiotic

REVIEW

 Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the ''''P'''' or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the ''''A'''' or acceptor site to the ''''P'''' or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug.

REFERENCES
[1]Kanazawa S, Ohkubo T, Sugawara K: The effects of grapefruit juice on the pharmacokinetics of erythromycin. Eur J Clin Pharmacol. 2001 Jan-Feb;56(11):799-803.
[2] Ogwal S, Xide TU: Bioavailability and stability of erythromycin delayed release tablets. Afr Health Sci. 2001 Dec;1(2):90-6.
[3] Okudaira T, Kotegawa T, Imai H, Tsutsumi K, Nakano S, Ohashi K: Effect of the treatment period with erythromycin on cytochrome P450 3A activity in humans. J Clin Pharmacol. 2007 Jul;47(7):871-6.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H317; H334

Precautionary Statements
P261; P272; P280; P285; P302+P352; P304+P341; P321; P333+P313; P342+P311; P363; P501


Current as of October 13, 2024


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All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives > Antibacterials, Macrolides


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