158681-13-1 Rimonabant HCl AKSci H760
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  H760    AKSci Reference Standard
Rimonabant HCl
, 98%

CAS Number:158681-13-1
MDL Number:MFCD00934884
Physical Form:White to almost white crystalline powder
Long-Term Storage:Store at room temperature
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III

Application(s):Selective antagonist of CB1
Form:HCl salt


 Rimonabant is a specific CB1 cannabinoid receptor antagonist. There is considerable evidence that the endocannabinoid (endogenous cannabinoid) system plays a significant role in appetitive drive and associated behaviours. It is therefore reasonable to hypothesize that the attenuation of the activity of this system would have therapeutic benefit in treating disorders that might have a component of excess appetitive drive or over-activity of the endocannabinoid system, such as obesity, ethanol and other drug abuse, and a variety of central nervous system and other disorders.

[1]Gelfand EV, Cannon CP: Rimonabant: a selective blocker of the cannabinoid CB1 receptors for the management of obesity, smoking cessation and cardiometabolic risk factors. Expert Opin Investig Drugs. 2006 Mar;15(3):307-15.
[2] Xie S, Furjanic MA, Ferrara JJ, McAndrew NR, Ardino EL, Ngondara A, Bernstein Y, Thomas KJ, Kim E, Walker JM, Nagar S, Ward SJ, Raffa RB: The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1 receptor antagonism-or inverse agonism-as potential obesity treatment and other therapeutic use. J Clin Pharm Ther. 2007 Jun;32(3):209-31.
[3] Cahill K, Ussher M: Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD005353.
[4] Maldonado R, Valverde O, Berrendero F: Involvement of the endocannabinoid system in drug addiction. Trends Neurosci. 2006 Apr;29(4):225-32. Epub 2006 Feb 17.



Signal Word

Hazard Statements
H301; H319

Precautionary Statements
P264; P270; P280; P301+P310; P305+P351+P338; P321; P330; P337+P313; P405; P501

Current as of May 29, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.

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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


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