21967-41-9 Baicalin AKSci H656
 
 
Loading Please Wait...
  H656    
Baicalin, 95% (HPLC)
 
Baicalein 7-O-glucuronide
7-D-Glucuronic acid-5,6-dihydroxyflavone
IDENTITY
CAS Number:21967-41-9
MDL Number:MFCD00134418
MF:C21H18O11
MW:446.36
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:215-219°C
Optical Rotation:-85° (c=1, in DMSO)
Density:1.738
Refractive Index:1.739
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Prolyl oligopeptidase inhibitor, induces apoptosis in pancreatic cancer cells, and affects GABA rec
Form:Free Base
Research Area:Neurological disease

REVIEW
 Baicalin, the naturally occurring glucuronide of the flavone baicalein, is found in several species in the genus Scutellaria, including Scutellaria lateriflora (blue skullcap). It is a component of Chinese medicinal herb Huang-chin (Scutellaria baicalensis) and one of the chemical ingredients of Sho-Saiko-To, an herbal supplement. Baicalin has been extensively researched for utility in a number of therapeutic areas owing to its anti-inflammatory, anti-oxidant, anti-bacterial, and anti-cancer properties. Baicalin is a known prolyl oligopeptidase inhibitor, induces apoptosis in pancreatic cancer cells, and affects the GABA receptors.

REFERENCES
[1]Shimizu I. Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma. J Gastroenterol Hepatol. 2000 Mar;15 Suppl:D84-90.
[2] Huang Y, Tsang SY, Yao X, Chen ZY, Biological properties of baicalein in cardiovascular system. Curr Drug Targets Cardiovasc Haematol Disord. 2005;5(2):177-84.
[3] Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev. 2009 ;35(1):57-68.
[4] Tarragó T, Kichik N, Claasen B, Prades R, Teixidó M, Giralt E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg Med Chem. 2008;16(15):7516-24.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives >


PubChem
  @PubMed