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BIOLOGICAL INFO
Solubility:
Soluble in ethanol (47 mg/ml at 25°C), chloroform, water (<1 mg/ml at 25°C), DMSO (47 mg/ml at 25°C), and acetone
Application(s):
An alkylating antitumor nitrosourea agent
Form:
Free Base
Research Area:
Cancer
REVIEW Lomustine is a highly lipophilic nitrosourea compound which undergoes hydrolysis in vivo to form reactive metabolites. These metabolites cause alkylation and cross-linking of DNA (at the O6 position of guanine-containing bases) and RNA, thus inducing cytotoxicity. Other biologic effects include inhibition of DNA synthesis and some cell cycle phase specificity. Nitrosureas generally lack cross-resistance with other alkylating agents. As lomustine is a nitrosurea, it may also inhibit several key processes such as carbamoylation and modification of cellular proteins.
All products are stocked and shipped from San Francisco Bay Area, California, USA.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
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WARNING: Attention California residents: This product can expose you to chemicals including Lomustine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.
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