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BIOLOGICAL INFO
Application(s):
An inhibitor of Cox-2 and tyrosine kinase
REVIEW Leflunomide is an immunosuppressive drug that inhibits T and B cell responses. Leflunomide is an inhibitor of Cox-2, of tyrosine phosphorylation (tyrosine kinase), of DHODH (dihydroorotate dehydrogenase), an enzyme for de novo pyrimidine synthesis, and of TNF-dependent NF-κB activation. The physiological activity of leflunomide is attributed mainly to its metabolite.
REFERENCES
[1]
Bartlett, R.R., et al. 1985. Int. J. Immunopharmacol. 7: 7-18. PMID: 3873420
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. CATEGORIES APIs and Bioactives > Pyrimidine Synthesis Inhibitors
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