13127-18-9 Erythromycin oxime AKSci H393
 
 
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  H393    AKSci Bulk Reagent
Erythromycin oxime, 93% (HPLC)
 
Erythromycin A Oxime (Roxithromycin Impurity C)
IDENTITY
CAS Number:13127-18-9
MDL Number:MFCD08062410
MF:C37H68N2O13
MW:748.94
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:93% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:155-165°C
Density:1.3
Refractive Index:1.55
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Antibiotic, A metabolite of Roxithromycin and intermediate of Azithromycin

REVIEW
 Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the ''''P'''' or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the ''''A'''' or acceptor site to the ''''P'''' or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug.

REFERENCES
[1]Kanazawa S, Ohkubo T, Sugawara K: The effects of grapefruit juice on the pharmacokinetics of erythromycin. Eur J Clin Pharmacol. 2001 Jan-Feb;56(11):799-803.
[2] Ogwal S, Xide TU: Bioavailability and stability of erythromycin delayed release tablets. Afr Health Sci. 2001 Dec;1(2):90-6.
[3] Okudaira T, Kotegawa T, Imai H, Tsutsumi K, Nakano S, Ohashi K: Effect of the treatment period with erythromycin on cytochrome P450 3A activity in humans. J Clin Pharmacol. 2007 Jul;47(7):871-6.
[4] Ferrero, J., et al.: Drug Metab. Dispos., 18, 441 (1990).

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 25, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Antibacterials, Macrolides


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