189188-57-6 Tegaserod maleate AKSci H172
 
 
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  H172    AKSci Reference Standard
Tegaserod maleate
, 98% (HPLC)
 
SDZ HTF 919, Zelnorm
Zelmac




IDENTITY
CAS Number:189188-57-6
MDL Number:MFCD04116201
MF:C16H23ON5.C4H4O4
MW:417.46
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:LCMS, HPLC
Physical Form:Off-white to light yellow crystalline powder
Melting Point:188-191°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Application(s):A SR-4 partial agonist

REVIEW

 Tegaserod is a 5-HT4 receptor partial agonist that binds with high affinity at human 5-HT4 receptors, whereas it has no appreciable affinity for 5-HT3 or dopamine receptors. It has moderate affinity for 5-HT1 receptors. Tegaserod, by acting as an agonist at neuronal 5-HT4 receptors, triggers the release of further neurotransmitters such as calcitonin gene-related peptide from sensory neurons. The activation of 5-HT4 receptors in the gastrointestinal tract stimulates the peristaltic reflex and intestinal secretion, as well as inhibits visceral sensitivity.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 4, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Serotonin Agonists


PubChem