20537-88-6 Amifostine AKSci H037
 
 
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  H037    AKSci Reference Standard
Amifostine
, 98% (HPLC)
 
Ethiofos
Gammaphos
Ethyol
more..




IDENTITY
CAS Number:20537-88-6
MDL Number:MFCD00233058
MF:C5H15N2O3PS
MW:214.22
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:NMR, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:160-166°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Application(s):A broad radio-chemoprotector, restores mutant p53 activity, upregulates HIF-1alfa, free radical scav

REVIEW

 The thiol metabolite is responsible for most of the cytoprotective and radioprotective properties of amifostine. It is readily taken up by cells where it binds to and detoxifies reactive metabolites of platinum and alkylating agents as well as scavenges free radicals. Other possible effects include inhibition of apoptosis, alteration of gene expression and modification of enzyme activity.

REFERENCES
[1]Santini V, Giles FJ: The potential of amifostine: from cytoprotectant to therapeutic agent. Haematologica. 1999 Nov;84(11):1035-42.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P261; P280; P305+P351+P338; P304+P340; P405; P501


Current as of August 21, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Chemotherapeutics


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