142340-99-6 Adefovir dipivoxyl AKSci G989
 
 
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  G989    AKSci Reference Standard
Adefovir dipivoxyl
, 98% (HPLC)
 
9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine




IDENTITY
CAS Number:142340-99-6
MDL Number:MFCD00869897
MF:C20H32N5O8P
MW:501.47
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:96-103°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 100mg/mL; H2O: <1mg/mL; EtOH: 100mg/mL
Application(s):Reverse Transcriptase Inhibitor
Form:Free base

REVIEW

 Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.

REFERENCES
[1]Maeng HJ, Chapy H, Zaman S, Pang KS (2012). Effects of 1alpha,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells. Eur J Pharm Sci. 46(3):149-66. PMID 22387228.
[2] Hadziyannis SJ, Sevastianos V, Rapti I, Vassilopoulos D, Hadziyannis E (2012). Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir. Gastroenterology. 143(3):629-36.e1. PMID 22659218.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P312; P322; P330; P363; P501


Current as of October 16, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antivirals;NNRTIs


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