142340-99-6 Adefovir dipivoxyl AKSci G989
 
 
Loading Please Wait...
  G989    AKSci Reference Standard
Adefovir dipivoxyl, 98% (HPLC)
 
9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine
IDENTITY
CAS Number:142340-99-6
MDL Number:MFCD00869897
MF:C20H32N5O8P
MW:501.47
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:96-103°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 100mg/mL; H2O: <1mg/mL; EtOH: 100mg/mL
Application(s):Reverse Transcriptase Inhibitor
Form:Free base

REVIEW
 Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.

REFERENCES
[1]Maeng HJ, Chapy H, Zaman S, Pang KS (2012). Effects of 1alpha,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells. Eur J Pharm Sci. 46(3):149-66. PMID 22387228.
[2] Hadziyannis SJ, Sevastianos V, Rapti I, Vassilopoulos D, Hadziyannis E (2012). Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir. Gastroenterology. 143(3):629-36.e1. PMID 22659218.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P312; P322; P330; P363; P501

Current as of April 19, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Antivirals;NNRTIs


PubChem