118292-40-3 Tazarotene AKSci G739
 
 
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  G739    AKSci Reference Standard
Tazarotene
, 98% (HPLC)
 
6-[(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester
Tazorac
Avage
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IDENTITY
CAS Number:118292-40-3
MDL Number:MFCD00867628
MF:C21H21NO2S
MW:351.46
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Spectra:NMR, FT-IR, LCMS, HPLC
Physical Form:White to light yellow powder
Melting Point:97-106°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >15mg/mL; H2O: <1mg/mL; EtOH: 10mg/mL
Application(s):Keratolytic Agent; Dermatologic Agent; Teratogen
Form:Free Base

REVIEW

 Tazarotene is a retinoid prodrug which is converted to its active form, the cognate carboxylic acid of tazarotene, by rapid deesterification in animals and man. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family: RAR-α RAR-β, and RAR-γ but shows relative selectivity for RAR-β, and RAR-γ and may modify gene expression.

REFERENCES
[1]Attar, Mayssa; Journal of Pharmaceutical Sciences 2005, V94(10), P2246-2255.
[2] Frigoli, Samuele; Organic Process Research & Development 2005, V9(5), P646-650.
[3] Galitzer BI (2012). Effect of retinoid pretreatment on outcomes of patients treated by photodynamic therapy for actinic keratosis of the hand and forearm. PMID 21968662.
[4] Tanghetti E, Dhawan S, Green L, Ling M, Downie J, Germain MA, Kasteler JS, Kircik L, Oefelein MG, Draelos Z (2012). Clinical evidence for the role of a topical anti-inflammatory agent in comedonal acne: findings from a randomized study of dapsone gel 5% in combination with tazarotene cream 0.1% in patients with acne vulgaris. J Drugs Dermatol. 10(7):783-92. PMID 21720661.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
None

Hazard Statements
H413

Precautionary Statements
P273; P501


Current as of September 27, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Dermatology


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