REVIEW Tazarotene is a retinoid prodrug which is converted to its active form, the cognate carboxylic acid of tazarotene, by rapid deesterification in animals and man. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family: RAR-α RAR-β, and RAR-γ but shows relative selectivity for RAR-β, and RAR-γ and may modify gene expression.
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Tanghetti E, Dhawan S, Green L, Ling M, Downie J, Germain MA, Kasteler JS, Kircik L, Oefelein MG, Draelos Z (2012). Clinical evidence for the role of a topical anti-inflammatory agent in comedonal acne: findings from a randomized study of dapsone gel 5% in combination with tazarotene cream 0.1% in patients with acne vulgaris. J Drugs Dermatol. 10(7):783-92. PMID 21720661.
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