119615-63-3 Olprinone hydrochloride AKSci G665
 
 
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  G665    
Olprinone hydrochloride, 98% (HPLC)
 
Loprinone hydrochloride
1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
IDENTITY
CAS Number:119615-63-3
MDL Number:MFCD01749474
MF:C14H11ClN4O
MW:286.72
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>300°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: <=4mg/mL; H2O: 7mg/mL
Application(s):Cardiotonic Agent; Phosphodiesterase 3 Inhibitor
Form:HCl salt

REVIEW
 Olprinone is a cardiotonic agent. It is a selective phosphodiesterase 3 (PDE3) inhibitor.

REFERENCES
[1]Genovese T, Mazzon E, Paterniti I, Esposito E, Cuzzocrea S (2011). Neuroprotective effects of olprinone after cerebral ischemia/reperfusion injury in rats. Neurosci Lett. 503(2):93-9. PMID 21872644.
[2] Kinouchi K, Morita K, Ko Y, Nagahori R, Shinohara G, Abe T, Hashimoto K (2012). Reversal of oxidant-mediated biochemical injury and prompt functional recovery after prolonged single-dose crystalloid cardioplegic arrest in the infantile piglet heart by terminal warm-blood cardioplegia supplemented with phosphodiesterase III inhibitor. Gen Thorac Cardiovasc Surg. 60(2):73-81. PMID 22327851.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 20, 2024


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⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

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