107007-99-8 Granisetron HCl AKSci G468
 
 
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  G468    
Granisetron HCl
, 98%
 
Kytril
1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide hydrochloride
1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride




IDENTITY
CAS Number:107007-99-8
MDL Number:MFCD01747034
MF:C18H24N4O.HCl
MW:348.87
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white crystalline powder
Melting Point:284-290°C
Long-Term Storage:Store at room temperature
UN #:Not hazmat

BIOLOGICAL INFO
Solubility:DMSO: 1mg/mL; H2O: >10mg/mL; EtOH: 1mg/mL
Application(s):5-HT3 receptor antagonist
Form:HCl salt

REVIEW

 Granisetron is a potent, selective antagonist of 5-HT3 receptors. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.

REFERENCES
[1]Gan TJ: Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same? CNS Drugs. 2005;19(3):225-38.
[2] Tan M: Granisetron: new insights into its use for the treatment of chemotherapy-induced nausea and vomiting. Expert Opin Pharmacother. 2003 Sep;4(9):1563-71.
[3] Feyer P, Seegenschmiedt MH, Steingraeber M: Granisetron in the control of radiotherapy-induced nausea and vomiting: a comparison with other antiemetic therapies. Support Care Cancer. 2005 Sep;13(9):671-8. Epub 2005 Jul 26.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of January 18, 2019


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CATEGORIES

 APIs and Bioactives > Serotonin Antagonists


PubChem